Gene Polymorphism of t-PA is Associated With Forearm Vascular Release Rate of t-PA
نویسندگان
چکیده
منابع مشابه
Gene polymorphism of t-PA is associated with forearm vascular release rate of t-PA.
We have observed marked interindividual differences in release rates of tissue-type plasminogen activator (t-PA) among healthy subjects. The objective of the current study was to test the hypothesis that there is an association between a genetic variation at the t-PA locus and the in vivo release rate of t-PA. Fifty-one healthy males were studied at rest in the morning and 27 of these were also...
متن کاملSmoking impairs bradykinin-stimulated t-PA release.
Bradykinin stimulates tissue plasminogen activator release from human endothelium through a flow-independent, B2 receptor-dependent mechanism. The present study tests the hypothesis that smoking impairs bradykinin-stimulated tissue plasminogen activator release. Graded doses of nitroprusside (1.6 to 6.4 microg/min), methacholine (3.2 to 12.8 microg/min), and bradykinin (100 to 400 ng/min) were ...
متن کاملCardiac sympathetic nerve stimulation triggers coronary t-PA release.
OBJECTIVE This study was undertaken to determine whether stimulation of sympathetic cardiac nerves induces release of the thrombolytic enzyme tissue-type plasminogen activator (t-PA) in the coronary vascular bed. METHODS AND RESULTS Anesthetized pigs were studied in an open chest model. Bilateral vagotomy was performed, and sympathetic cardiac nerves were activated by electrical stimulation (...
متن کاملتأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) بر عوامل فیبرینولیتیک (t-PA، PAI-1 و کمپلکس t-PA/PAI-1) مردان جوان غیرفعال
هدف از پژوهش حاضر، بررسی تأثیر شش هفته تمرین تناوبی با شدت بالا (HIIT) بر عوامل فیبرینولیتیک (t-PA، PAI-1 و کمپلکس t-PA/PAI-1) مردان جوان غیرفعال بود. به این منظور، 18 مرد جوان غیرفعال به‌صورت داوطلبانه در این پژوهش شرکت کردند و به‌طور تصادفی به دو گروه تجربی (9n=، سن:41/1±33/24 سال، قد:91/4±22/176 سانتی‌متر، وزن:59/6±27/72 کیلوگرم) و کنترل (9n=، سن:01/2±27/23 سال، قد:88/6±22/180 سانتی‌متر، وزن...
متن کاملEndovascular therapy after intravenous t-PA versus t-PA alone for stroke.
BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onse...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1999
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.19.2.454